BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE
- Product Name
- BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE
- CAS No.
- 88738-78-7
- Chemical Name
- BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE
- Synonyms
- NSC 634137;METHYL BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE;BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL);METHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE;METHYL P,P-BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE;METHYL O,O'-BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETATE;Methyl 2-(bis(2,2,2-trifluoroethoxy)-phosphoryl)acetate;Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate 95%;Methyl O,O'-bis(2,2,2-trifluoroethyl)phosphonoacetate,90%;BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETIC ACID METHYL ESTER
- CBNumber
- CB2475011
- Molecular Formula
- C7H9F6O5P
- Formula Weight
- 318.11
- MOL File
- 88738-78-7.mol
BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Property
- Boiling point:
- 246.6±40.0 °C(Predicted)
- Density
- 1.504 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.370(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- Specific Gravity
- 1.50
- color
- Clear orange to dark orange-brown
- BRN
- 3594044
- InChIKey
- PVSJXEDBEXYLML-UHFFFAOYSA-N
- CAS DataBase Reference
- 88738-78-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274259
- Product name
- Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate
- Purity
- 95%
- Packaging
- 5g
- Price
- $241
- Updated
- 2024/03/01
- Product number
- B1714
- Product name
- Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $51
- Updated
- 2024/03/01
- Product number
- B1714
- Product name
- Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $174
- Updated
- 2024/03/01
- Product number
- B1714
- Product name
- Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $678
- Updated
- 2024/03/01
- Product number
- Z3375
- Product name
- Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate
- Packaging
- 100g
- Price
- $1601
- Updated
- 2021/12/16
BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Chemical Properties,Usage,Production
Chemical Properties
clear orange to dark orange-brown liquid
Uses
Methyl?P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate can be used:
- In one of the key synthetic steps for the preparation of?trans-hydrindanes and (R)-(+)-umbelactone.
- To prepare a cis-olefinic ester derivative by Still–Gennari olefination of an aldehyde derivative using 18-crown ether and potassium bis(trimethylsilyl)amide (KHMDS).
- In the synthesis of (?)-(6S,2′S)-epi?cryptocaryalactone.
Synthesis
The synthesis method of Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl) phosphonate is as follows: To a stirred solution of dried 18-crown-6 (4.53 g, 17.14 mmol), THF (20 mL), and Bis(2,2,2-trifluoroethyl) Phosphite (0.70 mL, 1.29 mmol), was added KHMDS (9.0 mL, 4.50 mmol, 0.5M in toluene) by syringe in a dropwise manner at -78 ℃. After 15 min, methyl chloroacetate (0.30 mL, 3.41 mmol) was added and the reaction mixture was allowed to stir for 4 hr at room temperature. The reaction mixture was diluted with EtOAc (20 mL) and then quenched with sat. ammonium chloride (50 mL). The aqueous layer was extracted with EtOAc (3 x 30 mL). The combined organic extracts were dried under anhydrous magnesium sulfate. Following filtration, the solvents were removed in vacuo. The crude product was then purified by flash column chromatography (33% EtOAc in hexanes, Rf = 0.22 in 33% EtOAc in hexanes) yielding Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate (766 mg, 2.41 mmol, 70.3%) as a yellow syrup.
BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Preparation Products And Raw materials
Raw materials
Preparation Products
BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE Suppliers
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- Product
- BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE 88738-78-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19